New Discorhabdin D Analogues from Latrunculia spp. Sponges

Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3–6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2024-11, Vol.87 (11), p.2640-2648
Hauptverfasser:	Orfanoudaki, Maria, Dalilian, Masoumeh, Du, Lin, Chau, Cindy H., Figg, William D., O’Keefe, Barry R., Grkovic, Tanja
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology cell lines Drug Screening Assays, Antitumor Humans Molecular Structure neoplasm cells Nuclear Magnetic Resonance, Biomolecular Porifera - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3–6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.
ISSN:	0163-3864 1520-6025 1520-6025
DOI:	10.1021/acs.jnatprod.4c01036