Stable and Minimum Size Solubilization of Membrane Proteins with Cocktails of Phospholipid Analogues

Stable and Minimum Size Solubilization of Membrane Proteins with Cocktails of Phospholipid Analogues

Membrane proteins (MPs) play important roles in various cellular processes and are major targets for drugs. Solubilization of MPs is often needed for structural and biophysical studies. For high-resolution nuclear magnetic resonance measurements, there is a size limit of the sample (

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Veröffentlicht in:ACS applied materials & interfaces 2024-11, Vol.16 (46), p.63358-63367
Hauptverfasser: Takagi, Mai, Nagatani, Ayana, Kawano, Kenichi, Hata, Ayami, Yokoyama, Azusa, Hayashida, Koichi, Hoshi, Haruka, Sakurai, Mao, Oyama, Tsuyoshi, Kuroda, Yusuke, Yamaoka, Yousuke, Fujiwara, Takahiro, Miyanoiri, Yohei, Hoshino, Masaru, Yano, Yoshiaki, Takasu, Kiyosei, Matsuzaki, Katsumi
Format: Artikel
Sprache:eng
Schlagworte:
Biological and Medical Applications of Materials and Interfaces
Escherichia coli
humans
Influenza A virus
ligands
molecular weight
neuropeptides
nuclear magnetic resonance spectroscopy
phospholipids
quantum mechanics
solubility
solubilization
stabilizers
temperature
thermal stability
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Zusammenfassung:Membrane proteins (MPs) play important roles in various cellular processes and are major targets for drugs. Solubilization of MPs is often needed for structural and biophysical studies. For high-resolution nuclear magnetic resonance measurements, there is a size limit of the sample (
ISSN:1944-8244
1944-8252
1944-8252
DOI:10.1021/acsami.4c15697