Correlation between specific antibody response to wild-type BNT162b2 booster and the risk of breakthrough infection with omicron variants: Impact of household exposure in hospital healthcare workers

•Post-BNT162b2 booster anti-spike IgG titers of healthcare workers were measured.•SARS-CoV-2 exposures and breakthrough infections were recorded during an omicron epidemic.•Post-booster IgG titers were inversely correlated with a SARS-CoV-2 infection risk.•Household exposure was an important source...

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Veröffentlicht in:	Vaccine 2023-10, Vol.41 (45), p.6672-6678
Hauptverfasser:	Tani, Naoki, Ikematsu, Hideyuki, Goto, Takeyuki, Kondo, Satoko, Gondo, Kei, Fujiyoshi, Naoko, Minami, Junya, Harada, Yukiko, Nagano, Sukehisa, Horiuchi, Takahiko, Kuwano, Hiroyuki, Akashi, Koichi, Shimono, Nobuyuki, Chong, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibody antibody formation Antibody response Antigens Body mass index Breakthrough infection Close contact cohort studies Correlation COVID-19 COVID-19 vaccines Diagnostic tests Drug dosages Epidemics Exposure hazard ratio Health care Health risks health services Hospitals Households Immunoglobulin G Infections Interferon Laboratories Medical personnel Occupational exposure Omicron variant Proteins Risk SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Vaccine Vaccines γ-Interferon
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Zusammenfassung:	•Post-BNT162b2 booster anti-spike IgG titers of healthcare workers were measured.•SARS-CoV-2 exposures and breakthrough infections were recorded during an omicron epidemic.•Post-booster IgG titers were inversely correlated with a SARS-CoV-2 infection risk.•Household exposure was an important source of SARS-CoV-2 infection for healthcare workers.•Exposure with IgG titers of
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2023.09.051