High throughput detection of veterinary drug residues in chicken and eggs

Co-extraction of multiple types of target substances is the key to achieve high throughput detection. In this work, PDA@MOF-808/PAN NFsM was prepared by co-modified polyacrylonitrile nanofiber membrane (PAN NFsM) with polydopamine (PDA) and metal-organic framework-808 (MOF-808), and its potential as a solid-phase extraction (SPE) adsorbent was investigated by using the most typical nine veterinary drug residues in eggs and chicken as model target substances. The results show that PDA@MOF-808/PAN NFsM could effectively co-extract all the target substances (adsorption efficiency ranged from 81.46 % to 96.78 %), and had good capability of sample matrix purification (matrix effect was lower than −15.26 %), so a new SPE method has been established. Combined with UPLC-MS/MS, the detection limits were 0.3 to 3.1 μg/kg, the recoveries were between 71.02 % and 106.48 %, and the relative standard deviations were lower than 12.03 %, indicating that the method has considerable good sensitivity, accuracy and precision. •High throughput screening of a variety of veterinary drugs in chicken and egg samples was achieved.•PDA@MOF/PAN NFsM provides fast and efficient extraction of targets through multiple adsorption mechanisms.•PDA@MOF/PAN NFsM exhibited good purification ability for sample matrix.•The accuracy and sensitivity of this method both meet the requirements of practical applications.•The good practicality of the developed method was verified by testing actual samples.