Synthesis of C–N or C–C Spiroindolines via Rearrangement Coupling Reaction

Synthesis of C–N or C–C Spiroindolines via Rearrangement Coupling Reaction

Herein, we report a general approach to effectively construct C–N or C–C spiroindolines using tetrahydro-β-carbolines as starting materials via a rearrangement coupling reaction. This method is characterized by its operational simplicity and mild conditions. Notably, a wide range of anilines and ind...

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Veröffentlicht in:Organic letters 2024-11, Vol.26 (45), p.9759-9763
Hauptverfasser: Liu, Xiaoling, Qiao, Panpan, Chen, Hui, Gao, Yu, Chen, Haijun
Format: Artikel
Sprache:eng
Schlagworte:
aniline
couplings
indoles
methodology
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Zusammenfassung:Herein, we report a general approach to effectively construct C–N or C–C spiroindolines using tetrahydro-β-carbolines as starting materials via a rearrangement coupling reaction. This method is characterized by its operational simplicity and mild conditions. Notably, a wide range of anilines and indoles are suitable for this intermolecular coupling, yielding the corresponding C–N or C–C spiroindolines in good to excellent yields.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.4c03644