Candida antarctica lipase B catalyzed condensation reactions: Water mediated chemo-enzymatic synthesis of different heterocycles

[Display omitted] •Development of water mediated and enzyme catalyzed method towards heterocycles.•Environmentally friendly approach.•Synthesis and characterization of 27 different heterocycles in 76–92 % yield. A water-mediated, chemoenzymatic reaction has been developed for synthesizing various heterocycles. This reported method is compatible with various condensation reactions and multi-component reactions, such as the Biginelli reaction. It offers direct access to benzothiazole, benzimidazole, benzoxazole, quinazolinone, and pyrimidines using straightforward reaction conditions, adhering to green chemistry principles.