Prevalence of occult hepatitis C virus infection (OCI) among hemodialysis patients; a cross–sectional study from Lorestan Province, Western Iran
Patients with chronic kidney disorders, such as hemodialysis, are at a higher risk of infection with hepatitis viruses than the other population due to high nosocomial transmission by the dialysis units. The incidence of occult HCV infection (OCI) among chronic hemodialysis (CHD) remains controversi...
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description | Patients with chronic kidney disorders, such as hemodialysis, are at a higher risk of infection with hepatitis viruses than the other population due to high nosocomial transmission by the dialysis units. The incidence of occult
HCV
infection (OCI) among chronic hemodialysis (CHD) remains controversial and the real burden of
HCV
in this population may be affected by the rate of OCI. This study aimed to evaluate the prevalence of OCI among patients with CHD from Lorestan province, Western Iran. In this cross-sectional study, whole blood samples were collected from 122 patients with CHD. Subsequently, anti-
HCV
antibody and
HCV
-RNA were assessed in serum/peripheral blood mononuclear cells (PBMCs) using Enzyme-Linked Immunosorbent Assay and Real-Time PCR technique, respectively. Out of the 122 patients, 61.15% were male and 38.8% were female. Regarding
HCV
results, out of the 122 studied patients, 4 cases (3.3%) were positive for anti-HCV IgM Ab and 3 patients (2.47%) for anti-
HCV
IgG Ab in their serum. Moreover, none of the 122 patients were positive for
HCV
-RNA in serum samples, while in PBMC samples, two patients (1.6%) tested positive for
HCV
-RNA, of which one patient was anti-
HCV
IgG Ab positive. Furthermore, the prevalence of OCI was correlated with the history of blood transfusion and serum level of transaminases (
P
= 0.012). The results of the current study suggest that there is a potential risk of occult
HCV
infection among patients undergoing hemodialysis. Therefore, it is necessary to use appropriate molecular techniques for early diagnosis and treatment of these patients. |
doi_str_mv | 10.1007/s13337-024-00881-y |
format | Article |
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HCV
infection (OCI) among chronic hemodialysis (CHD) remains controversial and the real burden of
HCV
in this population may be affected by the rate of OCI. This study aimed to evaluate the prevalence of OCI among patients with CHD from Lorestan province, Western Iran. In this cross-sectional study, whole blood samples were collected from 122 patients with CHD. Subsequently, anti-
HCV
antibody and
HCV
-RNA were assessed in serum/peripheral blood mononuclear cells (PBMCs) using Enzyme-Linked Immunosorbent Assay and Real-Time PCR technique, respectively. Out of the 122 patients, 61.15% were male and 38.8% were female. Regarding
HCV
results, out of the 122 studied patients, 4 cases (3.3%) were positive for anti-HCV IgM Ab and 3 patients (2.47%) for anti-
HCV
IgG Ab in their serum. Moreover, none of the 122 patients were positive for
HCV
-RNA in serum samples, while in PBMC samples, two patients (1.6%) tested positive for
HCV
-RNA, of which one patient was anti-
HCV
IgG Ab positive. Furthermore, the prevalence of OCI was correlated with the history of blood transfusion and serum level of transaminases (
P
= 0.012). The results of the current study suggest that there is a potential risk of occult
HCV
infection among patients undergoing hemodialysis. Therefore, it is necessary to use appropriate molecular techniques for early diagnosis and treatment of these patients.</description><identifier>ISSN: 2347-3584</identifier><identifier>EISSN: 2347-3517</identifier><identifier>DOI: 10.1007/s13337-024-00881-y</identifier><identifier>PMID: 39464727</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Antibodies ; Biochemistry ; Biomedical and Life Sciences ; Blood levels ; blood serum ; Blood transfusion ; Blood transfusions ; Cell Biology ; Chronic infection ; cross infection ; Cross-sectional studies ; dialysis ; early diagnosis ; Enzyme-linked immunosorbent assay ; Enzymes ; females ; Gender ; Hemodialysis ; Hepatitis C ; Immunoglobulin G ; Immunoglobulin M ; Infections ; Iran ; Kidney diseases ; kidneys ; Leukocytes (mononuclear) ; Life Sciences ; Liver diseases ; males ; Microbiology ; Original Article ; Patients ; Peripheral blood mononuclear cells ; Population ; Population studies ; Protein Structure ; quantitative polymerase chain reaction ; Ribonucleic acid ; risk ; RNA ; Statistical analysis ; transaminases ; Viral infections</subject><ispartof>Virusdisease, 2024-09, Vol.35 (3), p.478-483</ispartof><rights>The Author(s), under exclusive licence to Indian Virological Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c204y-bd67b31862db6ccc8cd033ff1ca46d3192ac1cbecc072dd9d1bcbd8273b8ac473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13337-024-00881-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13337-024-00881-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39464727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasanvand, Banafsheh</creatorcontrib><creatorcontrib>Mirzaei, Habibollah</creatorcontrib><creatorcontrib>Hadian, Babak</creatorcontrib><creatorcontrib>sasaei, parsa</creatorcontrib><creatorcontrib>Garavand, Sara</creatorcontrib><creatorcontrib>Adhikary, Hemanta</creatorcontrib><creatorcontrib>Khanizadeh, Sayyad</creatorcontrib><title>Prevalence of occult hepatitis C virus infection (OCI) among hemodialysis patients; a cross–sectional study from Lorestan Province, Western Iran</title><title>Virusdisease</title><addtitle>VirusDis</addtitle><addtitle>Virusdisease</addtitle><description>Patients with chronic kidney disorders, such as hemodialysis, are at a higher risk of infection with hepatitis viruses than the other population due to high nosocomial transmission by the dialysis units. The incidence of occult
HCV
infection (OCI) among chronic hemodialysis (CHD) remains controversial and the real burden of
HCV
in this population may be affected by the rate of OCI. This study aimed to evaluate the prevalence of OCI among patients with CHD from Lorestan province, Western Iran. In this cross-sectional study, whole blood samples were collected from 122 patients with CHD. Subsequently, anti-
HCV
antibody and
HCV
-RNA were assessed in serum/peripheral blood mononuclear cells (PBMCs) using Enzyme-Linked Immunosorbent Assay and Real-Time PCR technique, respectively. Out of the 122 patients, 61.15% were male and 38.8% were female. Regarding
HCV
results, out of the 122 studied patients, 4 cases (3.3%) were positive for anti-HCV IgM Ab and 3 patients (2.47%) for anti-
HCV
IgG Ab in their serum. Moreover, none of the 122 patients were positive for
HCV
-RNA in serum samples, while in PBMC samples, two patients (1.6%) tested positive for
HCV
-RNA, of which one patient was anti-
HCV
IgG Ab positive. Furthermore, the prevalence of OCI was correlated with the history of blood transfusion and serum level of transaminases (
P
= 0.012). The results of the current study suggest that there is a potential risk of occult
HCV
infection among patients undergoing hemodialysis. Therefore, it is necessary to use appropriate molecular techniques for early diagnosis and treatment of these patients.</description><subject>Antibodies</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Blood levels</subject><subject>blood serum</subject><subject>Blood transfusion</subject><subject>Blood transfusions</subject><subject>Cell Biology</subject><subject>Chronic infection</subject><subject>cross infection</subject><subject>Cross-sectional studies</subject><subject>dialysis</subject><subject>early diagnosis</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>females</subject><subject>Gender</subject><subject>Hemodialysis</subject><subject>Hepatitis C</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Infections</subject><subject>Iran</subject><subject>Kidney diseases</subject><subject>kidneys</subject><subject>Leukocytes (mononuclear)</subject><subject>Life Sciences</subject><subject>Liver diseases</subject><subject>males</subject><subject>Microbiology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Peripheral blood mononuclear cells</subject><subject>Population</subject><subject>Population studies</subject><subject>Protein Structure</subject><subject>quantitative polymerase chain reaction</subject><subject>Ribonucleic acid</subject><subject>risk</subject><subject>RNA</subject><subject>Statistical analysis</subject><subject>transaminases</subject><subject>Viral infections</subject><issn>2347-3584</issn><issn>2347-3517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqNkc1q3TAQhUVpaEKSF-iiCLpJoU71Z8umq3Dpz4ULyaKlSyGP5FTBlm4l-4J3fYbmDfMkVa7TFLIoXY0YfefMMAehl5ScU0Lku0Q557IgTBSE1DUt5mfoiHEhC15S-fzxXYtDdJrSDSGEUilE1bxAh7wRlZBMHqFfV9HudG89WBw6HACmfsTf7VaPbnQJr_DOxSlh5zsLowsen12u1m-wHoK_ztwQjNP9nDJ6L7F-TO-xxhBDSnc_b9Mi0j1O42Rm3MUw4E2INo3a46sYdi5Pfou_5YaNHq-j9ifooNN9sqcP9Rh9_fjhy-pzsbn8tF5dbApgRMxFayrZclpXzLQVANRgCOddR0GLynDaMA0UWgtAJDOmMbSF1tRM8rbWICQ_RmeL7zaGH1NeQA0uge177W2YkuK0FLRkVLL_QBllNStLkdHXT9CbMMV8gT1FGCUNbzLFFmp_qGg7tY1u0HFWlKj7fNWSr8r5qn2-as6iVw_WUztY8yj5k2YG-AKk_OWvbfw7-x-2vwHEY7Pm</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Hasanvand, Banafsheh</creator><creator>Mirzaei, Habibollah</creator><creator>Hadian, Babak</creator><creator>sasaei, parsa</creator><creator>Garavand, Sara</creator><creator>Adhikary, Hemanta</creator><creator>Khanizadeh, Sayyad</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202409</creationdate><title>Prevalence of occult hepatitis C virus infection (OCI) among hemodialysis patients; a cross–sectional study from Lorestan Province, Western Iran</title><author>Hasanvand, Banafsheh ; Mirzaei, Habibollah ; Hadian, Babak ; sasaei, parsa ; Garavand, Sara ; Adhikary, Hemanta ; Khanizadeh, Sayyad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c204y-bd67b31862db6ccc8cd033ff1ca46d3192ac1cbecc072dd9d1bcbd8273b8ac473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antibodies</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Blood levels</topic><topic>blood serum</topic><topic>Blood transfusion</topic><topic>Blood transfusions</topic><topic>Cell Biology</topic><topic>Chronic infection</topic><topic>cross infection</topic><topic>Cross-sectional studies</topic><topic>dialysis</topic><topic>early diagnosis</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>females</topic><topic>Gender</topic><topic>Hemodialysis</topic><topic>Hepatitis C</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Infections</topic><topic>Iran</topic><topic>Kidney diseases</topic><topic>kidneys</topic><topic>Leukocytes (mononuclear)</topic><topic>Life Sciences</topic><topic>Liver diseases</topic><topic>males</topic><topic>Microbiology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Peripheral blood mononuclear cells</topic><topic>Population</topic><topic>Population studies</topic><topic>Protein Structure</topic><topic>quantitative polymerase chain reaction</topic><topic>Ribonucleic acid</topic><topic>risk</topic><topic>RNA</topic><topic>Statistical analysis</topic><topic>transaminases</topic><topic>Viral infections</topic><toplevel>online_resources</toplevel><creatorcontrib>Hasanvand, Banafsheh</creatorcontrib><creatorcontrib>Mirzaei, Habibollah</creatorcontrib><creatorcontrib>Hadian, Babak</creatorcontrib><creatorcontrib>sasaei, parsa</creatorcontrib><creatorcontrib>Garavand, Sara</creatorcontrib><creatorcontrib>Adhikary, Hemanta</creatorcontrib><creatorcontrib>Khanizadeh, Sayyad</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Virusdisease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasanvand, Banafsheh</au><au>Mirzaei, Habibollah</au><au>Hadian, Babak</au><au>sasaei, parsa</au><au>Garavand, Sara</au><au>Adhikary, Hemanta</au><au>Khanizadeh, Sayyad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of occult hepatitis C virus infection (OCI) among hemodialysis patients; a cross–sectional study from Lorestan Province, Western Iran</atitle><jtitle>Virusdisease</jtitle><stitle>VirusDis</stitle><addtitle>Virusdisease</addtitle><date>2024-09</date><risdate>2024</risdate><volume>35</volume><issue>3</issue><spage>478</spage><epage>483</epage><pages>478-483</pages><issn>2347-3584</issn><eissn>2347-3517</eissn><abstract>Patients with chronic kidney disorders, such as hemodialysis, are at a higher risk of infection with hepatitis viruses than the other population due to high nosocomial transmission by the dialysis units. The incidence of occult
HCV
infection (OCI) among chronic hemodialysis (CHD) remains controversial and the real burden of
HCV
in this population may be affected by the rate of OCI. This study aimed to evaluate the prevalence of OCI among patients with CHD from Lorestan province, Western Iran. In this cross-sectional study, whole blood samples were collected from 122 patients with CHD. Subsequently, anti-
HCV
antibody and
HCV
-RNA were assessed in serum/peripheral blood mononuclear cells (PBMCs) using Enzyme-Linked Immunosorbent Assay and Real-Time PCR technique, respectively. Out of the 122 patients, 61.15% were male and 38.8% were female. Regarding
HCV
results, out of the 122 studied patients, 4 cases (3.3%) were positive for anti-HCV IgM Ab and 3 patients (2.47%) for anti-
HCV
IgG Ab in their serum. Moreover, none of the 122 patients were positive for
HCV
-RNA in serum samples, while in PBMC samples, two patients (1.6%) tested positive for
HCV
-RNA, of which one patient was anti-
HCV
IgG Ab positive. Furthermore, the prevalence of OCI was correlated with the history of blood transfusion and serum level of transaminases (
P
= 0.012). The results of the current study suggest that there is a potential risk of occult
HCV
infection among patients undergoing hemodialysis. Therefore, it is necessary to use appropriate molecular techniques for early diagnosis and treatment of these patients.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>39464727</pmid><doi>10.1007/s13337-024-00881-y</doi><tpages>6</tpages></addata></record> |
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subjects | Antibodies Biochemistry Biomedical and Life Sciences Blood levels blood serum Blood transfusion Blood transfusions Cell Biology Chronic infection cross infection Cross-sectional studies dialysis early diagnosis Enzyme-linked immunosorbent assay Enzymes females Gender Hemodialysis Hepatitis C Immunoglobulin G Immunoglobulin M Infections Iran Kidney diseases kidneys Leukocytes (mononuclear) Life Sciences Liver diseases males Microbiology Original Article Patients Peripheral blood mononuclear cells Population Population studies Protein Structure quantitative polymerase chain reaction Ribonucleic acid risk RNA Statistical analysis transaminases Viral infections |
title | Prevalence of occult hepatitis C virus infection (OCI) among hemodialysis patients; a cross–sectional study from Lorestan Province, Western Iran |
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