Advances and prospects of tumor immunotherapy mediated by immune cell-derived biomimetic metal-organic frameworks

The clinical translational success of nanomedicine and immunotherapy has already proved the immense potential in the field of nanotechnology and immunization. However, the development of nanomedicine is confronted with challenges such as potential toxicity and unclear nano–bio interactions. The efficacy of immunotherapy is limited to only a few groups. Combining immunotherapy with nanomedicine for multi-modal treatment effectively compensates for the limitations of the above single therapy. Immune cell membrane camouflaged metal-organic frameworks (ICM-MOFs) have emerged as a simple yet promising multimodal treatment strategy that possess multifunctional nanoscale properties and exhibit immune cell-like behaviors of stealth, targeting and immunomodulation. Here, we comprehensively discuss the latest advancements in ICM-MOFs, with a focus on the challenges of mono-immunotherapy, the superiority of biomimetic coating for MOF functionalization, preparation methods, related action mechanisms and biomedical applications. Finally, we address the challenges and prospects for clinical translation. [Display omitted] •Metal-organic frameworks (MOFs) are a nano delivery system and a nano sensitizer.•Immune cell membranes contain various bioactive proteins and lipids.•Immune cell membrane coated metal-organic frameworks (ICM-MOFs) are reviewed•ICM-MOFs incorporate multimodal therapies to compensate for monotherapy limitations.•Challenges and outlook for ICM-MOFs development and application are discussed.