Chronic environmental level exposure to perfluorooctane sulfonate overshadows graphene oxide to induce apoptosis through activation of the ROS-p53-caspase pathway in marine medaka Oryzias melastigma

Chronic environmental level exposure to perfluorooctane sulfonate overshadows graphene oxide to induce apoptosis through activation of the ROS-p53-caspase pathway in marine medaka Oryzias melastigma

The widespread occurrence of perfluorooctane sulfonate (PFOS) and the mass production and application of graphene oxide (GO) lead to their inevitable release and interaction in the environment, which may enhance associated toxic impacts on aquatic organisms. This study elucidates the induction of ap...

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Veröffentlicht in:Chemosphere (Oxford) 2024-10, Vol.365, p.143374, Article 143374
Hauptverfasser: Xu, Nan, Jiang, Xilin, Liu, Yan, Junaid, Muhammad, Ahmad, Manzoor, Bi, Chunqing, Guo, Wenjing, Jiang, Chen'ao, Liu, Shulin
Format: Artikel
Sprache:eng
Schlagworte:
adults
animal growth
Apoptosis
caspase-8
cell cycle
graphene oxide
Graphene oxide (GO)
Marine medaka
nanomaterials
Oryzias melastigma
Perfluorooctane sulfonate (PFOS)
perfluorooctane sulfonic acid
reactive oxygen species
toxicity
Transcriptome analysis
transcriptomics
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Zusammenfassung:The widespread occurrence of perfluorooctane sulfonate (PFOS) and the mass production and application of graphene oxide (GO) lead to their inevitable release and interaction in the environment, which may enhance associated toxic impacts on aquatic organisms. This study elucidates the induction of apoptosis by 60-day chronic single and mixture exposures to environmentally relevant levels of PFOS (0.5 μg/L and 5 μg/L) and GO (1 mg/L) in adult marine medaka Oryzias melastigma. Results showed a significant increase (p 
ISSN:0045-6535
1879-1298
1879-1298
DOI:10.1016/j.chemosphere.2024.143374