The influence of prolonged aerobic exercise on cardiac, muscular, and renal biomarkers in trained individuals with obesity

The aim of this study was to investigate the influence of prolonged aerobic exercise on cardiac, muscular and renal inflammatory markers in a group of trained obese men. Seventeen men (aged 40 ± 6 years; body mass index [BMI] 31.3 ± 2.8 kg m , maximal oxygen uptake [V'O max] 41.5 ± 5.6 ml kg min ) ran a half, 30 km, or full marathon. Troponin I (cTnI), the n-terminal creatine kinase-myocardial band (CK-MB), pro b-type natriuretic peptide (NT-proBNP), lactate dehydrogenase (LDH), myoglobin, creatinine (CREA) and the estimated glomerular filtration rate (eGFR) were measured before (T0), immediately after (T1) and 3 days after the race (T2). The concentrations of cTnI, myoglobin, LDH, CK-MB and CREA significantly increased (P