High Selectivity Fluorescence and Electrochemical Dual-Mode Detection of Glutathione in the Serum of Parkinson’s Disease Model Mice and Humans

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of alpha-synuclein. Glutathione (GSH), a key antioxidant, is significantly depleted in PD patients. This study presents a dual-mode detection strategy for selec...

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Veröffentlicht in:	Analytical chemistry (Washington) 2025-01, Vol.97 (2), p.1318-1328
Hauptverfasser:	Dong, Hui, Chen, Weitian, Xu, Ke, Zheng, Linlin, Wei, Bingyu, Liu, Ruiyu, Yang, Jingru, Wang, Tao, Zhou, Yanli, Zhang, Yintang, Xu, Maotian
Format:	Artikel
Sprache:	eng
Schlagworte:	analytical chemistry Animal models Animals antioxidants blood serum Carbon carbon electrodes Carbon nanotubes cysteine detection limit disease models Disease Models, Animal Dopamine receptors Electrochemical analysis Electrochemical Techniques Electrochemistry Electrodes Fluorescence Fluorescent Dyes - chemistry Fluorescent indicators Glutathione Glutathione - blood Humans Hydrogen sulfide Limit of Detection Mice Movement disorders nanotubes Nanotubes, Carbon - chemistry Neurodegenerative diseases Parkinson Disease - blood Parkinson Disease - diagnosis Parkinson's disease Resorufin Spectrometry, Fluorescence Synuclein
Online-Zugang:	Volltext
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