Microwave-Assisted Synthesis of Bis-1,2,3-Triazole-Based Benzophenones, In Vitro Antimicrobial Activity, and Molecular Docking Studies

In this work, we have adopted an easy route to synthesize bis-1,2,3-triazole-based benzophenone compounds via a 1,3-dipolar cycloaddition reaction (Click chemistry). All the target compounds achieved better yields through the microwave-assisted method than the conventional method. Target compound structures were confirmed on the basis of the IR, H NMR, C NMR, and HR mass analysis. Additionally, we have carried out in vitro antibacterial and antifungal activities with ciprofloxacin and fluconazole standard drugs, respectively. Compounds 5b, 5f, 5i, 5k, and 5n were antibacterial, whereas 5a, 5e, 5g, 5i, and 5k showed promising antifungal activity with respect to standard drugs. Further, a molecular docking study performed against DNA gyrase and lanosterol 14-alpha demethylase envisioned promising binding interactions with a good docking score.