Ionic and nano calcium to reduce cadmium and arsenic toxicity in plants: Review of mechanisms and potentials

Contamination of agricultural soils with heavy metal(loid)s like arsenic (As) and cadmium (Cd) is an ever increasing concern for crop production, quality, and global food security. Numerous in-situ and ex-situ remediation approaches have been developed to reduce As and Cd contamination in soils. However, field-scale applications of conventional remediation techniques are limited due to the associated environmental risks, low efficacy, and large capital investments. Recently, calcium (Ca) and Ca-based nano-formulations have emerged as promising solutions with the large potential to mitigate As and Cd toxicity in soil for plants. This review provides comprehensive insights into the phytotoxic effects of As and Cd stress/toxicity and discusses the applications of Ca-based ionic and nano-agrochemicals to alleviate As and Cd toxicity in important crops such as rice, wheat, maize, and barley. Further, various molecular and physiological mechanisms induced by ionic and nano Ca to mitigate As and Cd stress/toxicity in plants are discussed. This review also critically analyzes the efficiency of these emerging Ca-based approaches, both ionic and nano-formulations, in mitigating As and Cd toxicity in comparison to conventional remediation techniques. Additionally, future perspectives and ecological concerns of the remediation approaches encompassing ionic and nano Ca have been discussed. Overall, the review provides an updated and in-depth knowledge for developing sustainable and effective strategies to address the challenges posed by As and Cd contamination in agricultural crops. [Display omitted] •As And Cd are toxic for plant growth and development.•Ca2+ stimulates stress-responsive genes and proteins in plants.•Ca2+ and Ca-NPs regulate a wide range of fundamental processes in plants.•Ca2+ and Ca-NPs raise plant tolerance towards As and Cd stress.