Pd-catalyzed heteroannulation of isoxazoles: Convergent synthesis of isoxazolo[5,4-c]quinolines

Pd-catalyzed heteroannulation of isoxazoles: Convergent synthesis of isoxazolo[5,4-c]quinolines

[Display omitted] Variously substituted isoxazolo[5,4-c]quinolines can be easily prepared in high yields by Pd-catalyzed heteroannulation of 5-carbonyl-4-haloisoxazoles with 2-aminophenylboronic acid derivatives. 4-Unsubstituted isoxazolo[5,4-c]quinolines can be readily modified at C4 via a chlorina...

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Veröffentlicht in:Tetrahedron letters 2023-01, Vol.114, p.154270, Article 154270
Hauptverfasser: Galenko, Ekaterina E., Zanakhov, Timur O., Novikov, Mikhail S., Khlebnikov, Alexander F.
Format: Artikel
Sprache:eng
Schlagworte:
2-Aminophenylboronic acid
acids
chlorination
Cross-coupling
Heteroannulation
Isoxazoles Isoxazolo[5,4-c]quinolines
Pd-catalyzed
quinolines
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Zusammenfassung:[Display omitted] Variously substituted isoxazolo[5,4-c]quinolines can be easily prepared in high yields by Pd-catalyzed heteroannulation of 5-carbonyl-4-haloisoxazoles with 2-aminophenylboronic acid derivatives. 4-Unsubstituted isoxazolo[5,4-c]quinolines can be readily modified at C4 via a chlorination/substitution sequence.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.154270