A template-based approach to the synthesis of 1,7-dioxaspiro[5.5]undecane spiroketal derivatives

A template-based approach to the synthesis of 1,7-dioxaspiro[5.5]undecane spiroketal derivatives

This work investigates the preparation of 1,7-dioxaspiro [5.5]undecane derivatives via the application of the template compound 2,8-bis(bromomethyl)-1,7-dioxaspiro [5.5]undecane and a series of catalysed carbonyl-ene reactions introducing aromatic and non-aromatic linkers to the heterocyclic system,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron 2023-06, Vol.140, p.133454, Article 133454
Hauptverfasser: Sheng, Li, Bhalla, Rajiv
Format: Artikel
Sprache:eng
Schlagworte:
catalytic activity
Cyclization
Ene reaction
heterocyclic compounds
Hydrolysis
Lewis acids
Natural products
Spiro compounds
toxins
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This work investigates the preparation of 1,7-dioxaspiro [5.5]undecane derivatives via the application of the template compound 2,8-bis(bromomethyl)-1,7-dioxaspiro [5.5]undecane and a series of catalysed carbonyl-ene reactions introducing aromatic and non-aromatic linkers to the heterocyclic system, providing an alternative approach to various marine toxin fragments. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2023.133454