Expanding the Chemical Diversity of Grisechelins via Heterologous Expression

Thiazole scaffold-based small molecules exhibit a range of biological activities and play important roles in drug discovery. Based on bioinformatics analysis, a putative biosynthetic gene cluster (BGC) for thiazole-containing compounds was identified from Streptomyces sp. SCSIO 40020. Heterologous e...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2024-02, Vol.87 (2), p.371-380
Hauptverfasser:	Liu, Wei, Zhai, Shilan, Zhang, Liping, Chen, Yuchan, Liu, Zhiyong, Ma, Wanli, Zhang, Tianyu, Zhang, Weimin, Ma, Liang, Zhang, Changsheng, Zhang, Wenjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology antibacterial properties biochemical pathways bioinformatics biosynthesis drugs gene targeting heterologous gene expression Magnetic Resonance Spectroscopy moieties multigene family Mycobacterium tuberculosis quinoline Salicylic Acid spectral analysis Streptomyces Streptomyces - chemistry Streptomyces - genetics Thiazoles X-ray diffraction
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