Goondansamycins A–H: Benzenoid Ansamycins from an Australian Volcanic Crater Soil-Derived Actinomadura sp. S4S-00069B08

A chemical investigation of Australian soil-derived bacteria Actinomadura sp. S4S-00069B08 yielded eight new benzenoid ansamycins, goondansamycins A–H. Goondansamycins feature rare 1,4-benzoxazin-3-one or o-diamino-p-benzoquinone moieties and can exist as both aglycones or 9-O-α-glycosides of either...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2024-05, Vol.87 (5), p.1471-1478
Hauptverfasser:	Han, Jianying, Bernhardt, Paul V., Capon, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomadura Australia Benzoquinones - chemistry Benzoquinones - pharmacology Crystallography, X-Ray Molecular Structure Soil Microbiology spectroscopy X-radiation
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container_end_page	1478
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container_title	Journal of natural products (Washington, D.C.)
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creator	Han, Jianying Bernhardt, Paul V. Capon, Robert J.
description	A chemical investigation of Australian soil-derived bacteria Actinomadura sp. S4S-00069B08 yielded eight new benzenoid ansamycins, goondansamycins A–H. Goondansamycins feature rare 1,4-benzoxazin-3-one or o-diamino-p-benzoquinone moieties and can exist as both aglycones or 9-O-α-glycosides of either d-rhodinose or d-amicetose. Structures were solved on the basis of detailed spectroscopy, including X-ray analysis.
doi_str_mv	10.1021/acs.jnatprod.4c00336
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subjects	Actinomadura Australia Benzoquinones - chemistry Benzoquinones - pharmacology Crystallography, X-Ray Molecular Structure Soil Microbiology spectroscopy X-radiation
title	Goondansamycins A–H: Benzenoid Ansamycins from an Australian Volcanic Crater Soil-Derived Actinomadura sp. S4S-00069B08
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