Goondansamycins A–H: Benzenoid Ansamycins from an Australian Volcanic Crater Soil-Derived Actinomadura sp. S4S-00069B08

Goondansamycins A–H: Benzenoid Ansamycins from an Australian Volcanic Crater Soil-Derived Actinomadura sp. S4S-00069B08

A chemical investigation of Australian soil-derived bacteria Actinomadura sp. S4S-00069B08 yielded eight new benzenoid ansamycins, goondansamycins A–H. Goondansamycins feature rare 1,4-benzoxazin-3-one or o-diamino-p-benzoquinone moieties and can exist as both aglycones or 9-O-α-glycosides of either...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2024-05, Vol.87 (5), p.1471-1478
Hauptverfasser: Han, Jianying, Bernhardt, Paul V., Capon, Robert J.
Format: Artikel
Sprache:eng
Schlagworte:
Actinomadura
Australia
Benzoquinones - chemistry
Benzoquinones - pharmacology
Crystallography, X-Ray
Molecular Structure
Soil Microbiology
spectroscopy
X-radiation
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Zusammenfassung:A chemical investigation of Australian soil-derived bacteria Actinomadura sp. S4S-00069B08 yielded eight new benzenoid ansamycins, goondansamycins A–H. Goondansamycins feature rare 1,4-benzoxazin-3-one or o-diamino-p-benzoquinone moieties and can exist as both aglycones or 9-O-α-glycosides of either d-rhodinose or d-amicetose. Structures were solved on the basis of detailed spectroscopy, including X-ray analysis.
ISSN:0163-3864
1520-6025
1520-6025
DOI:10.1021/acs.jnatprod.4c00336