Three new abietane diterpenoids from the aerial parts of Euphorbia fischeriana and their cytotoxic effects

Chemical investigation on the aerial parts of Euphorbia fischeriana resulted in the identification of eight abietane-type diterpenoids including three undescribed ones, named 3α-acetoxy-14-hydroxy-ent-abieta-8(9),13(15)-dien-16,12-olide (1), 3α,7β-dihydroxy-ent-abieta-11(12),13(15)-dien-16,12-olide (2), and 2β-hydroxy helioscopinolide B (3). Compound 1 exhibited moderate cytotoxic activities against the HL-60, SMMC-7721, and SGC-7901 cancer cells. [Display omitted] •Eight abietane diterpenoids were isolated from Euphorbia fischeriana.•The structures of three new diterpenoids (1–3) were unambiguously determined.•Compound 1 exhibited moderate cytotoxic activities against HL-60, SMMC-7721 and SGC-7901 cancer cells.