Facile microwave-assisted synthesis of Dialdehyde−β−Cyclodextrin for evaluation of angiogenesis in wound healing

An exponential growth in chronic non-healing wounds worldwide have propelled the dire need for the design of effectual interventions. Of late, dialdehyde polysaccharides have blossomed as novel antimicrobial agents. Yet, such dialdehydes, accomplished by periodate oxidation, are mostly synthesized by the conventional strategy. Microwave-assisted synthesis, as of today, finds greater relevance than conventional methods as it is environmentally more benign. This research contribution focuses on microwave-initiated rapid synthesis of dialdehyde−β−Cyclodextrin (DA−β−CD) for its efficient use in chronic wound healing. The antibacterial and antibiofilm activities of DA−β−CD were systematically assessed against Staphylococcus epidermidis. The hemocompatible and cytotoxicity were also evaluated. In vivo angiogenic potential was performed in chick embryo. The results altogether suggested that the microwaved product was endowed with improved aqueous solubility and fared better in terms of wound healing than the conventional product. [Display omitted] •Dialdehyde−β−Cyclodextrin synthesized by microwave-assisted periodate oxidation.•Microwaved product endowed with enhanced aqueous solubility.•Good antibacterial and antibiofilm properties against S. epidermidis.•Demonstrated good hemocompatibility and biocompatibility.•Notable angiogenesis observed in chick embryo and highly potent in wound healing.