Collective syntheses of five abietane-type diterpenoids using a polyene cyclization strategy

Collective syntheses of five abietane-type diterpenoids using a polyene cyclization strategy

[Display omitted] Using Au-catalyzed 1,3-acyloxy migration/cyclization/electrophilic aromatic substitution cascade as the key step, the first total synthesis of (±)-crotolaevigatone B, (±)-crotontomentosin D, (±)-pomiferin D, (±)-2α-acetoxy-abietatriene and (±)-miltiorin A have been achieved in 7–9...

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Veröffentlicht in:Tetrahedron letters 2024-04, Vol.140, p.155023, Article 155023
Hauptverfasser: Zhang, Ya-Ting, Hou, Xue-Wei, Cheng, Fu, Huo, Chen-Yu, Li, Jing, Xu, Xue-Tao, Zhu, Dao-Yong, Wang, Shao-Hua
Format: Artikel
Sprache:eng
Schlagworte:
Au-catalyzed
Collective syntheses of nature products
diterpenoids
Lewis acids
Polyene cyclization
wills
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Zusammenfassung:[Display omitted] Using Au-catalyzed 1,3-acyloxy migration/cyclization/electrophilic aromatic substitution cascade as the key step, the first total synthesis of (±)-crotolaevigatone B, (±)-crotontomentosin D, (±)-pomiferin D, (±)-2α-acetoxy-abietatriene and (±)-miltiorin A have been achieved in 7–9 steps, which will lay the foundation for further biological research.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2024.155023