The impact of estradiol supplementation on endometrial thickness and intrauterine insemination outcomes

The impact of estradiol supplementation on endometrial thickness and intrauterine insemination outcomes

The impact of estrogen supplementation during the follicular/proliferative phase on the endometrial lining thickness (EMT) prior to intrauterine insemination (IUI) remains largely unstudied. Our study examined changes in EMT and rates of clinical pregnancy, miscarriage, and live birth for all patien...

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Veröffentlicht in:Reproductive biology 2024-06, Vol.24 (2), p.100886, Article 100886
Hauptverfasser: Zhang, Wendy Y., McCracken, Megan, Dominguez, Lisandra Veliz, Zhang, Amy, Johal, Jasmyn, Aghajanova, Lusine
Format: Artikel
Sprache:eng
Schlagworte:
abortion (animals)
confidence interval
Endometrial thickness
endometrium
estradiol
Estradiol supplementation
Infertility
insemination
Intrauterine insemination
nationalities and ethnic groups
ovulation
pregnancy
Thin endometrium
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Zusammenfassung:The impact of estrogen supplementation during the follicular/proliferative phase on the endometrial lining thickness (EMT) prior to intrauterine insemination (IUI) remains largely unstudied. Our study examined changes in EMT and rates of clinical pregnancy, miscarriage, and live birth for all patients who completed an IUI cycle at Stanford Fertility Center from 2017–2023 (n = 2281 cycles). Cycles with estradiol supplementation (n = 309) were compared to reference cycles without supplementation (n = 1972), with the reference cohort further categorized into cycles with a pre-ovulatory EMT of
ISSN:1642-431X
2300-732X
DOI:10.1016/j.repbio.2024.100886