A natural adhesive-based nanomedicine initiates photothermal-directed in situ immunotherapy with durability and maintenance

Tumor immunotherapies have emerged as a promising frontier in the realm of cancer treatment. However, challenges persist in achieving localized, durable immunostimulation while counteracting the tumor's immunosuppressive environment. Here, we develop a natural mussel foot protein-based nanomedi...

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Veröffentlicht in:Biomaterials 2025-01, Vol.312, p.122751, Article 122751
Hauptverfasser: He, Yunhong, Sun, Hong, Bao, Hanxiao, Hou, Jue, Zhou, Qiaomei, Wu, Fan, Wang, Xuanhao, Sun, Mingli, Shi, Junhui, Tang, Guping, Bai, Hongzhen
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container_start_page 122751
container_title Biomaterials
container_volume 312
creator He, Yunhong
Sun, Hong
Bao, Hanxiao
Hou, Jue
Zhou, Qiaomei
Wu, Fan
Wang, Xuanhao
Sun, Mingli
Shi, Junhui
Tang, Guping
Bai, Hongzhen
description Tumor immunotherapies have emerged as a promising frontier in the realm of cancer treatment. However, challenges persist in achieving localized, durable immunostimulation while counteracting the tumor's immunosuppressive environment. Here, we develop a natural mussel foot protein-based nanomedicine with spatiotemporal control for tumor immunotherapy. In this nanomedicine, an immunoadjuvant prodrug and a photosensitizer are integrated, which is driven by their dynamic bonding and non-covalent assembling with the protein carrier. Harnessing the protein carrier's bioadhesion, this nanomedicine achieves a drug co-delivery with spatiotemporal precision, by which it not only promotes tumor photothermal ablation but also broadens tumor antigen repertoire, facilitating in situ immunotherapy with durability and maintenance. This nanomedicine also modulates the tumor microenvironment to overcome immunosuppression, thereby amplifying antitumor responses against tumor progression. Our strategy underscores a mussel foot protein-derived design philosophy of drug delivery aimed at refining combinatorial immunotherapy, offering insights into leveraging natural proteins for cancer treatment. [Display omitted]
doi_str_mv 10.1016/j.biomaterials.2024.122751
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subjects Adhesives - chemistry
Adjuvants, Immunologic - pharmacology
Animals
bioadhesion
biocompatible materials
cancer therapy
Cell Line, Tumor
domain
Drug delivery
durability
Female
Humans
immunosuppression
immunotherapy
Immunotherapy - methods
Mice
Mice, Inbred C57BL
mussels
nanomedicine
Nanomedicine - methods
Natural proteins
neoplasm antigens
neoplasm progression
neoplasms
Neoplasms - immunology
Neoplasms - therapy
philosophy
photosensitizing agents
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Photothermal ablation
Photothermal Therapy - methods
Proteins - chemistry
Tumor immunotherapy
Tumor Microenvironment - drug effects
title A natural adhesive-based nanomedicine initiates photothermal-directed in situ immunotherapy with durability and maintenance
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