A natural adhesive-based nanomedicine initiates photothermal-directed in situ immunotherapy with durability and maintenance
Tumor immunotherapies have emerged as a promising frontier in the realm of cancer treatment. However, challenges persist in achieving localized, durable immunostimulation while counteracting the tumor's immunosuppressive environment. Here, we develop a natural mussel foot protein-based nanomedi...
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Veröffentlicht in: | Biomaterials 2025-01, Vol.312, p.122751, Article 122751 |
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creator | He, Yunhong Sun, Hong Bao, Hanxiao Hou, Jue Zhou, Qiaomei Wu, Fan Wang, Xuanhao Sun, Mingli Shi, Junhui Tang, Guping Bai, Hongzhen |
description | Tumor immunotherapies have emerged as a promising frontier in the realm of cancer treatment. However, challenges persist in achieving localized, durable immunostimulation while counteracting the tumor's immunosuppressive environment. Here, we develop a natural mussel foot protein-based nanomedicine with spatiotemporal control for tumor immunotherapy. In this nanomedicine, an immunoadjuvant prodrug and a photosensitizer are integrated, which is driven by their dynamic bonding and non-covalent assembling with the protein carrier. Harnessing the protein carrier's bioadhesion, this nanomedicine achieves a drug co-delivery with spatiotemporal precision, by which it not only promotes tumor photothermal ablation but also broadens tumor antigen repertoire, facilitating in situ immunotherapy with durability and maintenance. This nanomedicine also modulates the tumor microenvironment to overcome immunosuppression, thereby amplifying antitumor responses against tumor progression. Our strategy underscores a mussel foot protein-derived design philosophy of drug delivery aimed at refining combinatorial immunotherapy, offering insights into leveraging natural proteins for cancer treatment.
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[Display omitted]</description><subject>Adhesives - chemistry</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>bioadhesion</subject><subject>biocompatible materials</subject><subject>cancer therapy</subject><subject>Cell Line, Tumor</subject><subject>domain</subject><subject>Drug delivery</subject><subject>durability</subject><subject>Female</subject><subject>Humans</subject><subject>immunosuppression</subject><subject>immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>mussels</subject><subject>nanomedicine</subject><subject>Nanomedicine - methods</subject><subject>Natural proteins</subject><subject>neoplasm antigens</subject><subject>neoplasm progression</subject><subject>neoplasms</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - therapy</subject><subject>philosophy</subject><subject>photosensitizing agents</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Photothermal ablation</subject><subject>Photothermal Therapy - methods</subject><subject>Proteins - chemistry</subject><subject>Tumor immunotherapy</subject><subject>Tumor Microenvironment - drug effects</subject><issn>0142-9612</issn><issn>1878-5905</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u3CAUhVHVKJlM8woV6qobTwHbYHcXJf2TImWTPbrG15o7svEUcKpRXr6kTqvu2gVCwLnniO8w9k6KnRRSfzjsOponSBgIxrhTQlU7qZSp5Su2kY1piroV9Wu2EbJSRaulumCXMR5EPotKnbOLspVKGqU37Omae0hLgJFDv8dIj1h0ELHP136esCdHHjl5SpQTIz_u5zSnPYYJxqKngC5lMXkeKS2cpmnxv57heOI_KO15n807GimdOPieT0A-YTZ3-IadDfkDePWyb9nD508PN1-Lu_sv326u7wqnGp0KNFIAmqoBELp2ZWuU7JyBYdBuaLSTxvUGO1dXqmpLJxsFunUlOtFVRrfllr1fbY9h_r5gTHai6HAcweO8RFvKujQiQ6z_LRUZXFPqvLbs4yp1YY4x4GCPgSYIJyuFfa7JHuzfNdnnmuxaUx5--5KzdJnxn9HfvWTB7SrAzOWRMNjoCDOzlbjtZ_qfnJ9Kl62T</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>He, Yunhong</creator><creator>Sun, Hong</creator><creator>Bao, Hanxiao</creator><creator>Hou, Jue</creator><creator>Zhou, Qiaomei</creator><creator>Wu, Fan</creator><creator>Wang, Xuanhao</creator><creator>Sun, Mingli</creator><creator>Shi, Junhui</creator><creator>Tang, Guping</creator><creator>Bai, Hongzhen</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-7022-2379</orcidid></search><sort><creationdate>202501</creationdate><title>A natural adhesive-based nanomedicine initiates photothermal-directed in situ immunotherapy with durability and maintenance</title><author>He, Yunhong ; Sun, Hong ; Bao, Hanxiao ; Hou, Jue ; Zhou, Qiaomei ; Wu, Fan ; Wang, Xuanhao ; Sun, Mingli ; Shi, Junhui ; Tang, Guping ; Bai, Hongzhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286t-e710ae748aa065c39721bc7aff6cf86c17cd7ebc542493c182a69c3ec0b47693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adhesives - chemistry</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>bioadhesion</topic><topic>biocompatible materials</topic><topic>cancer therapy</topic><topic>Cell Line, Tumor</topic><topic>domain</topic><topic>Drug delivery</topic><topic>durability</topic><topic>Female</topic><topic>Humans</topic><topic>immunosuppression</topic><topic>immunotherapy</topic><topic>Immunotherapy - methods</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>mussels</topic><topic>nanomedicine</topic><topic>Nanomedicine - methods</topic><topic>Natural proteins</topic><topic>neoplasm antigens</topic><topic>neoplasm progression</topic><topic>neoplasms</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - therapy</topic><topic>philosophy</topic><topic>photosensitizing agents</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Photothermal ablation</topic><topic>Photothermal Therapy - methods</topic><topic>Proteins - chemistry</topic><topic>Tumor immunotherapy</topic><topic>Tumor Microenvironment - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Yunhong</creatorcontrib><creatorcontrib>Sun, Hong</creatorcontrib><creatorcontrib>Bao, Hanxiao</creatorcontrib><creatorcontrib>Hou, Jue</creatorcontrib><creatorcontrib>Zhou, Qiaomei</creatorcontrib><creatorcontrib>Wu, Fan</creatorcontrib><creatorcontrib>Wang, Xuanhao</creatorcontrib><creatorcontrib>Sun, Mingli</creatorcontrib><creatorcontrib>Shi, Junhui</creatorcontrib><creatorcontrib>Tang, Guping</creatorcontrib><creatorcontrib>Bai, Hongzhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Yunhong</au><au>Sun, Hong</au><au>Bao, Hanxiao</au><au>Hou, Jue</au><au>Zhou, Qiaomei</au><au>Wu, Fan</au><au>Wang, Xuanhao</au><au>Sun, Mingli</au><au>Shi, Junhui</au><au>Tang, Guping</au><au>Bai, Hongzhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A natural adhesive-based nanomedicine initiates photothermal-directed in situ immunotherapy with durability and maintenance</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2025-01</date><risdate>2025</risdate><volume>312</volume><spage>122751</spage><pages>122751-</pages><artnum>122751</artnum><issn>0142-9612</issn><issn>1878-5905</issn><eissn>1878-5905</eissn><abstract>Tumor immunotherapies have emerged as a promising frontier in the realm of cancer treatment. However, challenges persist in achieving localized, durable immunostimulation while counteracting the tumor's immunosuppressive environment. Here, we develop a natural mussel foot protein-based nanomedicine with spatiotemporal control for tumor immunotherapy. In this nanomedicine, an immunoadjuvant prodrug and a photosensitizer are integrated, which is driven by their dynamic bonding and non-covalent assembling with the protein carrier. Harnessing the protein carrier's bioadhesion, this nanomedicine achieves a drug co-delivery with spatiotemporal precision, by which it not only promotes tumor photothermal ablation but also broadens tumor antigen repertoire, facilitating in situ immunotherapy with durability and maintenance. This nanomedicine also modulates the tumor microenvironment to overcome immunosuppression, thereby amplifying antitumor responses against tumor progression. Our strategy underscores a mussel foot protein-derived design philosophy of drug delivery aimed at refining combinatorial immunotherapy, offering insights into leveraging natural proteins for cancer treatment.
[Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>39121726</pmid><doi>10.1016/j.biomaterials.2024.122751</doi><orcidid>https://orcid.org/0000-0001-7022-2379</orcidid></addata></record> |
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subjects | Adhesives - chemistry Adjuvants, Immunologic - pharmacology Animals bioadhesion biocompatible materials cancer therapy Cell Line, Tumor domain Drug delivery durability Female Humans immunosuppression immunotherapy Immunotherapy - methods Mice Mice, Inbred C57BL mussels nanomedicine Nanomedicine - methods Natural proteins neoplasm antigens neoplasm progression neoplasms Neoplasms - immunology Neoplasms - therapy philosophy photosensitizing agents Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Photothermal ablation Photothermal Therapy - methods Proteins - chemistry Tumor immunotherapy Tumor Microenvironment - drug effects |
title | A natural adhesive-based nanomedicine initiates photothermal-directed in situ immunotherapy with durability and maintenance |
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