Electrochemical N‑Acylation of Sulfoximine with Hydroxamic Acid

Despite the widespread applications of sulfoximines, green and efficient access to functionalized sulfoximines remains a challenge. By employing an electrochemical strategy, we describe an approach for the construction of N-aroylsulfoximines, which features a broad substrate scope, mild reaction con...

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Veröffentlicht in:Journal of organic chemistry 2023-12, Vol.88 (24), p.17511-17520
Hauptverfasser: Huang, Wenxiu, Wang, Shoucai, Li, Mingzhe, Zhao, Longqiang, Peng, Mengyu, Kang, Chen, Jiang, Guangbin, Ji, Fanghua
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Sprache:eng
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Zusammenfassung:Despite the widespread applications of sulfoximines, green and efficient access to functionalized sulfoximines remains a challenge. By employing an electrochemical strategy, we describe an approach for the construction of N-aroylsulfoximines, which features a broad substrate scope, mild reaction conditions, safety on a gram scale, and no need for an external oxidant and transition metal catalysts.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.3c01903