Influence of structural organization on mucoadhesive properties of poloxamer-hyaluronic acid-based micelles and hydrogels: From molecular modelling to biointerfaces interactions

New pharmaceutical formulations have been proposed as strategies to improve transport and provide best conditions to control the drug release rate in specific biological environments, such as mucosa surfaces. Herein, formulations containing binary systems Poloxamer (PL) 407 15 % and PL 338 15 %, com...

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Veröffentlicht in:	Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2024-10, Vol.698, p.134527, Article 134527
Hauptverfasser:	Sepulveda, Anderson Ferreira, da Silva, Jéssica Bassi, Bruschi, Marcos Luciano, Franco, Margareth KKD, Yokaichiya, Fabiano, Tófoli, Giovana Radomille, Cereda, Cíntia Maria Saia, Rosso, Anabella Patricia, Giacomelli, Fernando Carlos, Scott, Ana Ligia, de Araujo, Daniele Ribeiro
Format:	Artikel
Sprache:	eng
Schlagworte:	bioadhesives biopharmaceuticals cytotoxicity Hyaluronic acid Hydrogels local anesthetics Micelles molecular dynamics mucins Mucoadhesion mucosa Poloxamers Structural organization
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