Cu(II)/PTABS-Promoted, Chemoselective Amination of HaloPyrimidines

Cu(II)/PTABS-Promoted, Chemoselective Amination of HaloPyrimidines

Chemoselective amination is a highly desired synthetic methodology, given its importance as a possible strategy to synthesize various drug molecules and agrochemicals. We, herein, disclose a highly chemoselective Cu­(II)-PTABS-promoted amination of pyrimidine structural feature containing different...

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Veröffentlicht in:Journal of organic chemistry 2024-07, Vol.89 (13), p.9243-9254
Hauptverfasser: Phulwale, Vikram, Shet, Harshita, Gunturu, Krishna Chaitanya, Rout, Smruti Rekha, Dandela, Rambabu, Adhav, Suyog, Kapdi, Anant R.
Format: Artikel
Sprache:eng
Schlagworte:
agrochemicals
amination
chemoselectivity
drugs
halogens
organic chemistry
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Zusammenfassung:Chemoselective amination is a highly desired synthetic methodology, given its importance as a possible strategy to synthesize various drug molecules and agrochemicals. We, herein, disclose a highly chemoselective Cu­(II)-PTABS-promoted amination of pyrimidine structural feature containing different halogen atoms.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.4c00171