Body part-specific development in termite caste differentiation: crosstalk between hormonal actions and developmental toolkit genes

In social insects, interactions among colony members trigger caste differentiation with morphological modifications. During caste differentiation in termites, body parts and caste-specific morphologies are modified during postembryonic development under endocrine controls such as juvenile hormone (JH) and ecdysone. In addition to endocrine factors, developmental toolkit genes such as Hox- and appendage-patterning genes also contribute to the caste-specific body part modifications. These toolkits are thought to provide spatial information for specific morphogenesis. During social evolution, the complex crosstalks between physiological and developmental mechanisms should be established, leading to the sophisticated caste systems. This article reviews recent studies on these mechanisms underlying the termite caste differentiation and addresses implications for the evolution of caste systems in termites. •Termites develop caste-specific morphologies by the regulations of endocrine factors through social interactions.•Crosstalks between patterning genes and endocrine factors lead the development of caste-specific morphological characteristics.•The evolution of eusociality and the associated genomic changes that lead the sophisticated caste system are also discussed.