Metabolic impact of high lipid low dextrose parenteral nutrition

Metabolic impact of high lipid low dextrose parenteral nutrition

Parenteral nutrition (PN) containing 100% soybean oil lipids and high amounts of dextrose may lead to liver dysfunction and hyperglycemia. Mixed lipids have less pro-inflammatory components, so higher doses may be given to decrease the amount of dextrose provided. The purpose of this study is to pro...

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Veröffentlicht in:Clinical nutrition ESPEN 2023-10, Vol.57, p.213-218
Hauptverfasser: Adorno, Andrew, Ghio, Michael, Simpson, John Tyler, Rogers, Nathaniel, Guidry, Chrissy
Format: Artikel
Sprache:eng
Schlagworte:
alkaline phosphatase
blood glucose
C-reactive protein
clinical nutrition
glucose
hospitals
Hyperglycemia
insulin
Lipids
liver
Liver enzymes
parenteral feeding
Parenteral nutrition
prealbumin
soybean oil
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Zusammenfassung:Parenteral nutrition (PN) containing 100% soybean oil lipids and high amounts of dextrose may lead to liver dysfunction and hyperglycemia. Mixed lipids have less pro-inflammatory components, so higher doses may be given to decrease the amount of dextrose provided. The purpose of this study is to provide a descriptive analysis of patients who received PN with high mixed lipid and low dextrose content versus PN with lower 100% soybean oil lipid and high dextrose content. We retrospectively reviewed 62 patients aged ≥18 years receiving PN ≥ 7 days from 2016 to 2021 in an acute care hospital. Participants were divided into two groups: high lipid low dextrose (HLLD) containing a four-oil lipid (>30% kcal or ≥1 g/kg) vs adequate lipid high dextrose (ALHD) containing a 100% soybean oil lipid (
ISSN:2405-4577
2405-4577
DOI:10.1016/j.clnesp.2023.07.002