TFEB/LAMP2 contributes to PM0.2-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes

•PM0.2 exposure induced the disorders of α-syn degradation in mice and astrocytes.•LAMP2-mediated autophagy-lysosome pathway was disturbed and underlied α-syn pathology induced by PM0.2 exposure.•PP242 improved the disorder of α-syn through TFEB/LAMP2 pathway. Atmospheric particulate matter (PM) exa...

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Veröffentlicht in:	Journal of environmental sciences (China) 2024-11, Vol.145, p.117-127
Hauptverfasser:	Li, Ben, Liu, Ting, Shen, Yongmei, Qin, Jiangnan, Chang, Xiaohan, Wu, Meiqiong, Guo, Jianquan, Liu, Liangpo, Wei, Cailing, Lyu, Yi, Tian, Fengjie, Yin, Jinzhu, Wang, Tong, Zhang, Wenping, Qiu, Yulan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer disease Astrocytes autophagy Autophagy-lysosome brain cathepsin B inflammation mammals membrane proteins particle size particulates PM0.2 rapamycin risk factors therapeutics toxicity transcription factors α-Synuclein
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Zusammenfassung:	•PM0.2 exposure induced the disorders of α-syn degradation in mice and astrocytes.•LAMP2-mediated autophagy-lysosome pathway was disturbed and underlied α-syn pathology induced by PM0.2 exposure.•PP242 improved the disorder of α-syn through TFEB/LAMP2 pathway. Atmospheric particulate matter (PM) exacerbates the risk factor for Alzheimer's and Parkinson's diseases (PD) by promoting the alpha-synuclein (α-syn) pathology in the brain. However, the molecular mechanisms of astrocytes involvement in α-syn pathology underlying the process remain unclear. This study investigated PM with particle size
ISSN:	1001-0742 1878-7320
DOI:	10.1016/j.jes.2023.09.036