Study on the Role of Mitophagy Receptor PHB2 in Doubly Uniparental Inheritance of Hyriopsis cumingii

In bivalves, the heterogeneity of mitochondrial DNA and its unique mode of transmission have been the focus of attention, which is called doubly uniparental inheritance (DUI). Prohibitin-2 ( phb2 ) is a mitochondrial inner membrane protein that is a key mitophagy receptor for parental mitochondrial...

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Veröffentlicht in:	Marine biotechnology (New York, N.Y.) N.Y.), 2023-10, Vol.25 (5), p.790-799
Hauptverfasser:	Wang, Yayu, Zhu, Xiaoyue, Gu, Yang, Liu, Zongyu, Mao, Yingrui, Liu, Xiaojun, Bai, Zhiyi, Wang, Guiling, Li, Jiale
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals autophagosomes Autophagy Biomedical and Life Sciences Bivalvia Bivalvia - genetics Bivalvia - metabolism China Complementary DNA Conserved sequence DNA, Mitochondrial Engineering family Female Females Freshwater Freshwater & Marine Ecology Freshwater molluscs freshwater mussels Freshwater organisms Gametocytes Genes genetic markers gonads Heredity Heterogeneity Hyriopsis cumingii Inland water environment Life Sciences Localization Male Membrane proteins Microbiology Mitochondria Mitochondria - genetics Mitochondrial DNA Mitophagy Mitophagy - genetics Mollusks Mussels Nucleotide sequence Ovaries Prohibitin Receptors Semen - metabolism siRNA species Spermatogonia Spermatozoa Unionidae - genetics Zoology
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Zusammenfassung:	In bivalves, the heterogeneity of mitochondrial DNA and its unique mode of transmission have been the focus of attention, which is called doubly uniparental inheritance (DUI). Prohibitin-2 ( phb2 ) is a mitochondrial inner membrane protein that is a key mitophagy receptor for parental mitochondrial removal. Hyriopsis cumingii is a freshwater bivalve in China, the full-length cDNA of H. cumingii phb2 (named Hcphb2 ) is 2917 bp and encodes a total of 300 amino acids, a highly conserved sequence. Hcphb2 was highly expressed in the ovary. In the gonadal tissues of 5- to 8-month-old female mussels, the expression level of Hcphb2 continued to significantly increase. After Hcphb2 siRNA interference in 6-month-old female mussels, the expression of M-COII , a marker gene on M-type mitochondria, showed a considerable increase ( p
ISSN:	1436-2228 1436-2236
DOI:	10.1007/s10126-023-10240-5