Correlation of mir-221-3p differential expression with clinical characteristics of gastric cancer patients

Background Gastric cancer (GC) is one of the most common digestive malignancies. Although miR-221-3p was defined as a novel biomarker in many types of cancer, the relationship between its expression differences and the clinicopathological characteristics and prognosis of GC patients was yet to be fu...

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Veröffentlicht in:Molecular biology reports 2024-12, Vol.51 (1), p.69-69, Article 69
Hauptverfasser: Ma, Jichun, Li, Xingliang, Qiu, Zhisheng, Zhu, Ciba, Wu, Ziyao, Da, Mingxu
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Sprache:eng
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Zusammenfassung:Background Gastric cancer (GC) is one of the most common digestive malignancies. Although miR-221-3p was defined as a novel biomarker in many types of cancer, the relationship between its expression differences and the clinicopathological characteristics and prognosis of GC patients was yet to be fully understood. Methods and results TCGA database was utilized to predict the potential biological function of miR-221-3p in GC. QRT-PCR and RNA FISH were performed to detect the expression levels of miR-221-3p in GC. The miR-221-3p expression levels in GC tissues and cells were significantly higher than those in paracancerous tissues ( p  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-023-08924-1