Green synthesis of zinc and nickel dual-doped cerium oxide nanoparticles: antioxidant activity and cytotoxicity effects
Cerium oxide nanoparticles (CeO 2 -NPs) and Zn–Ni dual-doped CeO 2 -NPs were synthesized through a green approach by the implication of zucchini peel ( Cucurbita pepo ) extract as a capping and reduction agent. All the synthesized samples were studied by the results of FTIR, UV–Vis, XRD, and FESEM/E...
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Veröffentlicht in: | Bioprocess and biosystems engineering 2023-11, Vol.46 (11), p.1569-1578 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Cerium oxide nanoparticles (CeO
2
-NPs) and Zn–Ni dual-doped CeO
2
-NPs were synthesized through a green approach by the implication of
zucchini peel
(
Cucurbita pepo
) extract as a capping and reduction agent. All the synthesized samples were studied by the results of FTIR, UV–Vis, XRD, and FESEM/EDAX/PSA analyses. The Zn–Ni dual-doped CeO
2
-NPs contained a spherical morphology and their size was observed to increase at higher temperatures. The conducted MTT assay on the Huh-7 cell line displayed 50% of cells annihilation as a result of using undoped CeO
2
-NPs and Zn–Ni dual-doped CeO
2
-NPs at the inhibitory concentrations (IC
50
) of 700 and 185.4 μg/mL, respectively. We also evaluated the enzymatic functionality of
SOD
and
CAT
of undoped CeO
2
-NPs and dual-doped NPs and found it to be dose dependent. Moreover, Zn–Ni dual-doped CeO
2
-NPs intensified the
CAT
activity without causing any changes in
SOD
activity in similar concentrations.
Graphical Abstract |
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ISSN: | 1615-7591 1615-7605 |
DOI: | 10.1007/s00449-023-02920-2 |