Green synthesis of zinc and nickel dual-doped cerium oxide nanoparticles: antioxidant activity and cytotoxicity effects

Cerium oxide nanoparticles (CeO 2 -NPs) and Zn–Ni dual-doped CeO 2 -NPs were synthesized through a green approach by the implication of zucchini peel ( Cucurbita pepo ) extract as a capping and reduction agent. All the synthesized samples were studied by the results of FTIR, UV–Vis, XRD, and FESEM/E...

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Veröffentlicht in:Bioprocess and biosystems engineering 2023-11, Vol.46 (11), p.1569-1578
Hauptverfasser: Mahmoodi, Pegah, Motavalizadehkakhky, Alireza, Darroudi, Majid, Mehrzad, Jamshid, Zhiani, Rahele
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Sprache:eng
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Zusammenfassung:Cerium oxide nanoparticles (CeO 2 -NPs) and Zn–Ni dual-doped CeO 2 -NPs were synthesized through a green approach by the implication of zucchini peel ( Cucurbita pepo ) extract as a capping and reduction agent. All the synthesized samples were studied by the results of FTIR, UV–Vis, XRD, and FESEM/EDAX/PSA analyses. The Zn–Ni dual-doped CeO 2 -NPs contained a spherical morphology and their size was observed to increase at higher temperatures. The conducted MTT assay on the Huh-7 cell line displayed 50% of cells annihilation as a result of using undoped CeO 2 -NPs and Zn–Ni dual-doped CeO 2 -NPs at the inhibitory concentrations (IC 50 ) of 700 and 185.4 μg/mL, respectively. We also evaluated the enzymatic functionality of SOD and CAT of undoped CeO 2 -NPs and dual-doped NPs and found it to be dose dependent. Moreover, Zn–Ni dual-doped CeO 2 -NPs intensified the CAT activity without causing any changes in SOD activity in similar concentrations. Graphical Abstract
ISSN:1615-7591
1615-7605
DOI:10.1007/s00449-023-02920-2