Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C–H Activation

Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C–H Activation

Isoquinolone is one of the most common heterocyclic core structures in countless natural products and many bioactive compounds. Here, a highly efficient approach to synthesize isoquinolone scaffolds on DNA via rhodium­(III)-catalyzed C–H activation has been described. This chemistry transformation i...

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Veröffentlicht in:Organic letters 2024-04, Vol.26 (16), p.3338-3342
Hauptverfasser: Ye, Yusong, Berry, Madeline, Bock, William J., Cheng, Kunpeng, Nair, Sajiv K., Park, Christiana S., Patman, Ryan L., Sakata, Sylvie, Tran-Dubé, Michelle, Donaldson, Joyann S., Yang, Guanyu, Liu, Guansai
Format: Artikel
Sprache:eng
Schlagworte:
carbon-hydrogen bond activation
Catalysis
DNA
DNA - chemistry
heterocyclic compounds
Isoquinolines - chemical synthesis
Isoquinolines - chemistry
Molecular Structure
rhodium
Rhodium - chemistry
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Zusammenfassung:Isoquinolone is one of the most common heterocyclic core structures in countless natural products and many bioactive compounds. Here, a highly efficient approach to synthesize isoquinolone scaffolds on DNA via rhodium­(III)-catalyzed C–H activation has been described. This chemistry transformation is robust and has shown good compatibility with DNA, which is suitable for DNA-encoded library synthesis.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.4c00604