Chromones from the endophytic fungus Bipolaris eleusines

Eight previously undescribed chromones eleusineketones A–H (1–8), as well as eight known compounds (9–16), were isolated from the endophytic fungus Bipolaris eleusines. These planar structures were created using an in-depth analysis of their spectral data, which included 1D, 2D, and HRESIMS data. Furthermore, the absolute configurations of compounds 1, 2, and 6 were determined by spectroscopic analysis and quantum chemical computational approaches, and compound 5 was determined by single-crystal X-ray diffraction analysis. The cytotoxic activity assay revealed that compounds 1 and 5 both inhibited MDA-MB-231 cells with IC50 values of 14.48 μM and 17.99 μM, respectively. [Display omitted] •Eight undescribed chromones were isolated from the endophytic fungus B. eleusines.•Their configurations were determined through X-ray, ECD and 13C NMR calculation.•Compounds 1 and 5 displayed cytotoxic activities against MDA-MB-231 cells.