Hotter days, stronger immunity? Exploring the impact of rising temperatures on insect gut health and microbial relationships

Climate change can generate cascading effects on animals through compounding stressors. As ectotherms, insects are particularly susceptible to variation in temperature and extreme events. How insects respond to temperature often occurs with respect to their environment, and a pertinent question involves how thermal stress integrates with insect capabilities to resolve interactions with gut microorganisms (microbiome and gut pathogens). We explore the impact of elevated temperatures and the impact of the host physiological response influencing immune system regulation and the gut microbiome. We summarize the literature involving how elevated temperature extremes impact insect gut immune systems, and how in turn that alters potential interactions with the gut microbiome and potential pathogens. Temperature effects on immunity are complex, and ultimate effects on microbial components can vary by system. Moreover, there are multiple questions yet to explore in how insects contend with simultaneous abiotic stressors and potential trade-offs in their response to opportunistic microbiota. •Host immune responses are linked to stress responses.•Microorganisms have adaptive strategies to tolerate temperature fluctuations.•Elevated temperature may disrupt gut microbial communities and alter host immunity.•Changes in gut microbiota can lead to reduced host fitness or buffer thermal stress, depending upon the system.