Risk factors affecting quality of life in children with epilepsy and their caregivers: A secondary analysis of a cross-sectional online survey in Japan

•An online survey was conducted among caregivers of children with diagnosed epilepsy.•Quality of life (QOL) for caregivers was significantly lower than that of the general population.•Disability significantly impacted QOL and burden among caregivers and children.•Rescue medications may reduce the need for emergency transport affecting QOL among caregivers and children. This study aimed to evaluate the quality of life (QOL) in children with epilepsy and their caregivers, as well as the caregiver burden, through a secondary analysis of a cross-sectional online survey in Japan. Eligible participants were caregivers of children (aged