Treatment Effects in Pharmacological Clinical Randomized Controlled Trials are Mainly Due to Placebo

The placebo response in clinical trials has four components: regression to the mean (RTM), measurement artefacts, natural tendency (NT) of the disease, and the genuine placebo effect. Our objective is to determine what contributes to the size of the placebo-effect in clinical trials by meta-regressions of randomized placebo-controlled clinical trials. We identified five diseases where data on the rates of NT were available to search for a sample of n=150 (5x30) RCTs. We extracted various study descriptors and performed meta-regressions to predict improvement in treatment and placebo groups. We sampled 30 trials each from the following diagnoses: osteoarthritis of the knee, irritable bowel syndrome, depression, sleep disorders, migraine, and extracted relevant information. We estimated the effects due to RTM and NT and analyzed the improvement in placebo and treatment groups by fitting two regression models. Both models were highly significant, explaining 72% of the variance. Improvement in the placebo group can be significantly predicted by improvement in the treatment group (beta= .84), whether a study was analyzed according to intention to treat (beta= -.10) or was a multicenter study (beta= .12). Improvement in the treatment group can be explained by the improvement in the placebo group (beta= .83), whether a study was a multi-center trial (beta = -.16), and by RTM (beta= -.18). The treatment effect is smaller in sleep studies (beta= -.17). The high correlation of r= .73 between placebo improvement and treatment improvement rates is genuine and not explainable by study or disease characteristics. We conclude from our data that the placebo-effect is the major driver of treatment effects in clinical trials that alone explains 69% of the variance. This leaves only limited space for effects due to pharmacological substances. Context effects are more important than pharmacological ones in the conditions studied by us. •Meta-regression were used to assess placebo-effects in pharmacological RCTs•The analyses accounted for natural history and regression to the mean•∼72% of treatment outcomes could be explained by other factors than treatment itself•Pharmacological effects explain only up to 28% of observed improvements•Contextual factors like expectations and doctor-patient interactions drive healing