Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha-Synuclein Disease

Remote identification of individuals with severe hyposmia may enable scalable recruitment of participants with underlying alpha-synuclein aggregation. We evaluated the performance of a staged screening paradigm using remote smell testing to enrich for abnormal dopamine transporter single-photon emis...

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Veröffentlicht in:Annals of neurology 2024-12
Hauptverfasser: Brown, Ethan G, Chahine, Lana M, Siderowf, Andrew, Gochanour, Caroline, Kurth, Ryan, Marshall, Micah J, Caspell-Garcia, Chelsea, Brumm, Michael C, Stanley, Jr, Craig E, Korell, Monica, McMahon, Bridget, Kuhl, Maggie, Fabrizio, Kimberly, Heathers, Laura, Concha-Marambio, Luis, Soto, Claudio, Chowdhury, Sohini, Coffey, Christopher S, Foroud, Tatiana M, Simuni, Tanya, Marek, Kenneth, Tanner, Caroline M
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Sprache:eng
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Zusammenfassung:Remote identification of individuals with severe hyposmia may enable scalable recruitment of participants with underlying alpha-synuclein aggregation. We evaluated the performance of a staged screening paradigm using remote smell testing to enrich for abnormal dopamine transporter single-photon emission computed tomography imaging (DAT-SPECT) and alpha-synuclein aggregation. The Parkinson's Progression Markers Initiative (PPMI) recruited participants for the prodromal cohort who were 60-years and older without a Parkinson's disease diagnosis. Participants were invited to complete a University of Pennsylvania Smell Identification Test (UPSIT) independently through an online portal. Hyposmic participants were invited to complete DAT-SPECT, which determined eligibility for enrollment in longitudinal assessments and further biomarker evaluation including cerebrospinal fluid alpha-synuclein seed amplification assay (aSynSAA). As of January 29, 2024, 49,843 participants were sent an UPSIT and 31,293 (63%) completed it. Of UPSIT completers, 8,301 (27%) scored
ISSN:1531-8249
1531-8249
DOI:10.1002/ana.27158