Pollonein-LAAO unveiling anti-angiogenic effects through oxidative stress: Insights from mimetic tumor angiogenesis environment in a 3D co-culture model

Pollonein-LAAO unveiling anti-angiogenic effects through oxidative stress: Insights from mimetic tumor angiogenesis environment in a 3D co-culture model

[Display omitted] •Pollonein-LAAO increased intracellular reactive oxygen species in HUVECs.•Pollonein-LAAO inhibited tube vessel formation and tumor growth in 3D culture models.•Oxidative stress induced by Pollonein-LAAO inhibited HUVECs adhesion, migration and invasion.•Pollonein-LAAO downregulate...

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Veröffentlicht in:Chemico-biological interactions 2024-12, Vol.406, p.111361, Article 111361
Hauptverfasser: Polloni, Lorena, Costa, Tássia Rafaella, Morais, Lorena Pinheiro, Borges, Bruna Cristina, Teixeira, Samuel Cota, de Melo Fernandes, Thales Alves, Correia, Lucas Ian Veloso, Bastos, Luciana Machado, Soares, Andreimar Martins, Silva, Marcelo José Barbosa, Amália Vieira Ferro, Eloisa, Lopes, Daiana Silva, Ávila, Veridiana de Melo Rodrigues
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Sprache:eng
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Zusammenfassung:[Display omitted] •Pollonein-LAAO increased intracellular reactive oxygen species in HUVECs.•Pollonein-LAAO inhibited tube vessel formation and tumor growth in 3D culture models.•Oxidative stress induced by Pollonein-LAAO inhibited HUVECs adhesion, migration and invasion.•Pollonein-LAAO downregulated VEGFA, ANGPT-2, MMP2, MMP9, ITGA2 expression.•Pollonein-LAAO promoted actin cytoskeleton alteration in HUVECs.
ISSN:0009-2797
1872-7786
1872-7786
DOI:10.1016/j.cbi.2024.111361