Unravelling the potential of natural chelating agents in the control of Staphylococcus aureus and Pseudomonas aeruginosa biofilms

Iron is essential for the formation, maturation and dispersal of bacterial biofilms, playing a crucial role in the physiological and metabolic functions of bacteria as well as in the regulation of virulence. Limited availability of iron can impair the formation of robust biofilms by altering cellula...

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Veröffentlicht in:	European journal of medicinal chemistry 2025-02, Vol.283, p.117163, Article 117163
Hauptverfasser:	Leitão, Miguel M., Gonçalves, Ariana S.C., Moreira, Joana, Fernandes, Carlos, Borges, Fernanda, Simões, Manuel, Borges, Anabela
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxy-4-pyrone derivatives Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiofilm activity Biofilms - drug effects Biological Products - chemistry Biological Products - pharmacology Chelating activity Chelating Agents - chemistry Chelating Agents - pharmacology Dose-Response Relationship, Drug Dual combinations Iron Chelating Agents - chemistry Iron Chelating Agents - pharmacology Microbial Sensitivity Tests Molecular Structure Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - physiology Pseudomonas aeruginosa biofilms Pyrones - chemistry Pyrones - pharmacology Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Staphylococcus aureus biofilms Structure-Activity Relationship
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