Antioxidant, Anticancer, Hepatoprotective and Wound Healing Activity of Fucopyranose (Sulfated Polysaccharides) from Padina pavonica (L.)

The emergence of various diseases such as cardiovascular, aging and cancer are due to oxidative stress as well as the shortage of enough antioxidant materials. Our study was intended to analyze the anticancer, antimicrobial, wound healing as well as hepatoprotective activities of purified sulfated polysaccharides derived from P. pavonica. The sulfated polysaccharide was subjected to partial purification using DEAE cellulose. The sulfated fraction was identified by HPLC, FTIR, 1 H-NMR and GC–MS. The results showed that the presence of fucopyranose in sulfated polysaccharide was attached to the O - acetyl groups confirmed by 1 H-NMR analysis. Further P. pavonica was carried out for the antioxidant profiling of sulfated polysaccharide through various standard assays. Bioactive principles of sulfated polysaccharides in medicinal fields were confirmed by anticancer activity on MDA-MB-231 breast cancer cells and wound healing activity in four groups of albino rats. The hepatoprotective activity of sulfated fraction was determined based on their biochemical parameters. Emulsification activity of sulfated polysaccharide was also evaluated. Also, it has antimicrobial properties. Our report has pointed out that the supplementation of sulfated polysaccharides would prevent the formation of cancer and oxidative damage of biomolecules.