Heterogeneity of Clinical Phenotypes in Severe Acute Respiratory Infections due to Respiratory Syncytial Virus: A Need to Look Beyond Hospitalization

Heterogeneity of Clinical Phenotypes in Severe Acute Respiratory Infections due to Respiratory Syncytial Virus: A Need to Look Beyond Hospitalization

To use a pre-COVID-19 birth cohort database to describe the clinical heterogeneity of severe acute respiratory infections (SARI) cases of the past seasons as a basis to investigate further distribution of clinical phenotypes in the era of immunization for respiratory syncytial virus (RSV). Infants w...

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Veröffentlicht in:The Journal of pediatrics 2024-12, p.114441, Article 114441
Hauptverfasser: Horvat, Côme, Duclaux-Loras, Lélia, Ouziel, Antoine, Butin, Marine, Couray-Targe, Sandrine, Myard-Dury, Anne-Florence, Haesebaert, Julie, Massoud, Mona, Benchaib, Mehdi, Ploin, Anne, Gillet, Yves, Lina, Bruno, Casalegno, Jean-Sebastien, Ploin, Dominique, Panetta, Luc, Javouhey, Etienne, Claris, Olivier, Gaucherand, Pascal, Massardier, Jerome, Vanhems, Philippe, Bin, Sylvie, Polazzi, Stephanie, Cartier, Regine, Morfin, Florence, Jourdain, Marine, Valette, Martine, Ottmann, Michelle, Terrier, Olivier, Fiorini, Sylvie, Rivat, Nathalie, Renard, Florent, Roy-Cordero, Alvaro, Jaakkola, Kaisa, Portefaix, Aurélie, Nunes, Marta, Chauvel, Cecile, Mekki, Yahia, Wallet, Florent, Touzet, Sandrine, Ader, Florence, Conrad, Anne
Format: Artikel
Sprache:eng
Schlagworte:
Cohort Study
Infant
Lower Respiratory Tract Infection
Phenotype
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Zusammenfassung:To use a pre-COVID-19 birth cohort database to describe the clinical heterogeneity of severe acute respiratory infections (SARI) cases of the past seasons as a basis to investigate further distribution of clinical phenotypes in the era of immunization for respiratory syncytial virus (RSV). Infants with RSV-SARI were identified from a 2014 through 2019 birth cohort in a tertiary care center in Lyon, France, and their medical records extensively reviewed. Using the criteria of the World Health Organization severity definitions, we classified SARI as having nutritional (inability to feed), respiratory (SpO2
ISSN:0022-3476
1097-6833
1097-6833
DOI:10.1016/j.jpeds.2024.114441