Discovery of Cyclic Lipopeptides, Octaminomycins C and D, by Engineering LysR Transcriptional Regulator of Streptomyces sp

New lipodepsipeptides, octaminomycins C and D (1 and 2), were discovered in an engineered Streptomyces sp. strain overexpressing the LysR transcriptional regulator family. The structures of 1 and 2 were elucidated by comprehensive analysis of their UV, HRMS, and NMR data. The absolute configurations...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2024-12, Vol.87 (12), p.2822-2828
Hauptverfasser:	An, Joon Soo, Kim, Jung Min, Han, Jaeho, Lee, Jun Young, Nam, Sang-Jip, Lee, Sang Kook, Yoon, Yeo Joon, Oh, Dong-Chan
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Depsipeptides - chemistry Depsipeptides - pharmacology Lipopeptides - biosynthesis Lipopeptides - chemistry Molecular Structure Peptide Synthases - genetics Peptide Synthases - metabolism Peptides, Cyclic - chemistry Streptomyces - chemistry Streptomyces - genetics Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	New lipodepsipeptides, octaminomycins C and D (1 and 2), were discovered in an engineered Streptomyces sp. strain overexpressing the LysR transcriptional regulator family. The structures of 1 and 2 were elucidated by comprehensive analysis of their UV, HRMS, and NMR data. The absolute configurations were determined using spectroscopic analysis, the advanced Marfey’s method, and genomic analysis. Genomic analysis enabled the identification of the nonribosomal peptide synthetase (NRPS) biosynthetic pathway of the octaminomycins.
ISSN:	0163-3864 1520-6025 1520-6025
DOI:	10.1021/acs.jnatprod.4c01047