Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy

Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy

Application of multivariate curve resolution to non-invasive Raman spectra has been investigated for rapid on-line analysis of crystallisation processes and high-throughput screening. Exploring quantification of mefenamic acid solid forms (form I, form II, and dimethylformamide solvate) from the Ram...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2024-12
Hauptverfasser: Chong, Magdalene W S, Ward, Martin R, McFarlan, Catriona, Parrott, Andrew J, Dallin, Paul, Andrews, John, Oswald, Iain D H, Nordon, Alison
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Sprache:eng
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Zusammenfassung:Application of multivariate curve resolution to non-invasive Raman spectra has been investigated for rapid on-line analysis of crystallisation processes and high-throughput screening. Exploring quantification of mefenamic acid solid forms (form I, form II, and dimethylformamide solvate) from the Raman spectra indicated excellent agreement with off-line X-ray analysis.
ISSN:1364-548X
1364-548X
DOI:10.1039/d4cc05591h