Chimeric antigen receptor copies in cell‐free DNA predict relapse in aggressive B‐cell lymphoma patients treated with CAR T‐cell therapy
Summary Chimeric antigen receptor (CAR) T‐cell therapy has emerged as a transformative treatment for aggressive B‐cell lymphomas (ABCL), However, about half of patients relapse, most of them early. This study investigates the detection of CAR copies in circulating cell‐free DNA (cfDNA) as a potentia...
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Veröffentlicht in: | British journal of haematology 2025-01, Vol.206 (1), p.195-203 |
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Hauptverfasser: | , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Summary
Chimeric antigen receptor (CAR) T‐cell therapy has emerged as a transformative treatment for aggressive B‐cell lymphomas (ABCL), However, about half of patients relapse, most of them early. This study investigates the detection of CAR copies in circulating cell‐free DNA (cfDNA) as a potential predictive biomarker of early relapse ( |
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ISSN: | 0007-1048 1365-2141 1365-2141 |
DOI: | 10.1111/bjh.19916 |