Intra-abdominal hypertension and pancreatic destruction in patients with acute necrotizing pancreatitis

Aim: To determine the relationship between intra-abdominal hypertension and the volume of pancreatogenic necrosis in patients with acute necrotizing pancreatitis. Materials and Methods: A prospective single-center study of 32 adults with acute necrotizing pancreatitis (ANP). A correlation was made between the maximum intra-abdominal pressure (IAP) in the early phase of the disease and the area of pancreatic necrosis and extrapancreatic necrosis (EPN) according to CT data. A one-factor linear regression model was built, based on the linear dependence of the volume of EPN on the maximum value of IAP. Results: A positive correlation between the IAP level and the volume of EPN was revealed, ρ = 0.547 (p=0.0012). No linear correlation between the level of IAP and the degree of necrosis of the pancreas (p=0.368). The volume of EPN was related to the indicator of IAP(p