Cervical cancer in young women: Does age impact survival in cervical cancer?

•Cervical cancer patients 25 years old or younger had similar RFS and OS compared to older patients.•In the subgroup analysis by tumor differentiation, young patients with undifferentiated tumors (G3) showed a worse RFS.•Advanced stage, hydronephrosis and patients not adherent to treatment were independently associated with worse survival. To evaluate the oncology outcomes in cervical cancer patients aged 25 years or younger and compare them with those in older patients. Cervical cancer patients were retrospectively analyzed and divided into two groups: young patients (≤25 years) and older patients (>25 years). For each young patient, two controls were selected from the database of cervical cancer patients aged over 25 years, matched by FIGO stage, treatment, and histologic type. A total of 138 patients were included, 46 patients aged 25 years or younger and 92 patients aged over 25 years. Of young patients, stage III was the most common, with 21 (45.5 %) patients, while stages I, II and IV occurred in 12 (26.2 %), 8 (17.4 %) and 5 (10.9 %) patients, respectively. The 5-year RFS (75 % and 73 %; P = 0.91) and 5-year OS (60 % and 67 %; P = 0.45) were not significantly different between the groups. After multivariate analysis age had no significant impact on OS (HR 1.25, 95 % CI 0.68–2.30; P = 0.46) or RFS (HR 0.95, 95 % CI 0.43–2.10; P = 0.91). Cervical cancer patients aged 25 years or younger did not present a worse OS and RFS compared to patients aged over 25 years.