Finding ochronotic sclera and ear discoloration in a 75-year-old man leads to a diagnosis of alkaptonuria

[...]the patient had prostate stones aged 73 years which were diagnosed after he reported difficulties with micturition; he had a transurethral resection of his prostate. [...]cost approval for treatment with nitisinone was requested, approved, and started 5 months later. Ochronosis describes the accumulation process of homogentisic acid as pigmented deposits in connective tissues; large joints, the cardiovascular system—including heart valves and the intima of vessels; the urogenital system, the skin, and the eyes may be affected, leading to tissue or organ dysfunction and significantly impacting the quality of life.