Subcellular ToF-SIMS Imaging of the Snow Alga Sanguina nivaloides by Combining High Mass and High Lateral Resolution Acquisitions

Subcellular ToF-SIMS Imaging of the Snow Alga Sanguina nivaloides by Combining High Mass and High Lateral Resolution Acquisitions

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging has demonstrated great potential for metabolic imaging; however, achieving sufficiently high lateral and mass resolution to reach the organelle scale remains challenging. To address this, we have developed an approach that combines im...

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Veröffentlicht in:Analytical chemistry (Washington) 2024-12, Vol.96 (50), p.19917-19925
Hauptverfasser: Seydoux, Claire, Ezzedine, Jade A., Larbi, Grégory Si, Ravanel, Stéphane, Maréchal, Eric, Barnes, Jean-Paul, Jouneau, Pierre-Henri
Format: Artikel
Sprache:eng
Schlagworte:
Multivariate Analysis
Organelles - chemistry
Organelles - metabolism
Spectrometry, Mass, Secondary Ion - methods
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Zusammenfassung:Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging has demonstrated great potential for metabolic imaging; however, achieving sufficiently high lateral and mass resolution to reach the organelle scale remains challenging. To address this, we have developed an approach that combines imaging acquisitions close to the highest lateral resolution (
ISSN:0003-2700
1520-6882
1520-6882
DOI:10.1021/acs.analchem.4c03826