MiR-363: A potential biomarker of kidney diseases

•MiR-363 plays an important role in various renal diseases.•MiRNA-363 in renal diseases should examine its specificity, sensitivity, and molecular mechanisms in different renal diseases.•MiRNA-363 has the potential to be an early biomarker of kidney diseases. MicroRNAs (miRNAs), a class of endogenou...

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Veröffentlicht in:Clinica chimica acta 2025-02, Vol.567, p.120049, Article 120049
Hauptverfasser: Huang, Yiqi, Zhou, Jiazhen, Deng, Yaotang, Li, Guoliang, He, Shuirong, Li, Hecheng, Liu, Lili
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Sprache:eng
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Zusammenfassung:•MiR-363 plays an important role in various renal diseases.•MiRNA-363 in renal diseases should examine its specificity, sensitivity, and molecular mechanisms in different renal diseases.•MiRNA-363 has the potential to be an early biomarker of kidney diseases. MicroRNAs (miRNAs), a class of endogenous small RNAs with lengths of approximately 19–24 nucleotides, play important regulatory roles in cells. In recent years, miR-363 has emerged as a prominent member of the miR-92a family, participating in various biological functions, including cellular proliferation, cycle, migration, and apoptosis. In particular, miR-363 plays a critical role in acute kidney injury, renal fibrosis, and diabetic nephropathy and can serve as a biomarker for the diagnosis of renal cell carcinoma. Ongoing research is exploring its potential as a biomarker of other kidney diseases. This review focuses on the role of miR-363 in kidney diseases, elucidating its regulatory mechanisms and exploring its possible value as a biomarker of kidney diseases.
ISSN:0009-8981
1873-3492
1873-3492
DOI:10.1016/j.cca.2024.120049